PHARMALEADS

AMINO ACID DERIVATIVES CONTAINING A DISULFANYL GROUP AS AN INHIBITOR OF NEP AND APN FOR THE PREVENTION AND TREATMENT OF TRIGEMINAL NERVE PAIN

N° US2023241021A1

Process for industrial preparation of the disodium salt of ((2s)-3-([1,1'-biphenyl]-4-yl)-2- ((hydroxy((1r)-1-(((1- (isobutyryloxy) ethoxy) carbonyl) amino) ethyl) phosphoryl) methyl) propanoyl)-l-alanine

N° IL293793A

METHOD FOR THE INDUSTRIAL PREPARATION OF THE DISODIUM SALT OF ((2S)-3-([1,1'-BIPHENYL]-4-YL)-2-((HYDROXY((1R)-1-(((1-(ISOBUTYRYLOXY)ETHOXY)CARBONYL)AMINO)ETHYL)PHOSPHORYL) METHYL)PROPANOYL)-L-ALANINE

N° ZA202205454B

N-FORMYLHYDROXYLAMINES AS NEPRILYSIN (NEP) INHIBITORS, IN PARTICULAR AS MIXED AMINOPEPTIDASE N (APN) AND NEPRILYSIN (NEP) INHIBITORS

N° ZA202200411B

N-formylhydroxylamines as neprilysin (nep) inhibitors, in particular as mixed aminopeptidase n (apn) and neprilysin (nep) inhibitors

N° IL289517A

INDUSTRIAL PROCESS FOR PREPARING (5S,10S)-10-BENZYL-16-METHYL-11,14,18-TRIOXO-15,17,19-TRIOXA-2,7,8-TRITHIA-12-AZAHENICOSAN-5-AMINIUM(E)-3-CARBOXYL ACRYLATE SALT

N° JP2021193127A

Method for the industrial preparation of the disodium salt of ((2S)-3-([1,1′-biphenyl]-4-yl-2-((hydroxy((1R)-1-(((1-(isobutyryloxy)ethoxy)carbonyl)amino)ethyl)phosphoryl) methyl)propanoyl)-l-alanine

N° US2023041504A1

PROCESS FOR INDUSTRIAL PREPARATION OF THE DISODIUM SALT OF ((2S)-3-([1,1'-BIPHENYL]-4-YL)-2-((HYDROXY((1R)-1-(((1-(ISOBUTY RYLOXY)ETHOXY)CARBONYL)AMINO)ETHYL)PHOSPHORYL)METHYL)PROPANOYL)- L-ALANINE.

N° MX2022007205A

PROCESS FOR INDUSTRIAL PREPARATION OF THE DISODIUM SALT OF ((2S)-3-([1,1'-BIPHENYL]-4-YL)-2-((HYDROXY((1R)-1-(((1-(ISOBUTYRYLOXY)ETHOXY)CARBONYL)AMINO)ETHYL)PHOSPHORYL)METHYL)PROPANOYL)-L-ALANINE

N° WO2021116617A1

PROCESS FOR INDUSTRIAL PREPARATION OF THE DISODIUM SALT OF ((2S)-3-([1,1'-BIPHENYL]-4-YL)-2-((HYDROXY((1R)-1-(((1-(ISOBUTYRYLOXY)ETHOXY)CARBONYL)AMINO)ETHYL)PHOSPHORYL)METHYL)PROPANOYL)-L-ALANIN

N° CA3157968A1

MÉTODO PARA A PREPARAÇÃO INDUSTRIAL DO SAL DISSÓDICO DE ((2S)-3-([1,1'-BIFENIL]-4-IL)-2-((HIDRÓXI((1R)-1-(((1-(ISOBUTIRILÓXI)ETÓXI)CARBONIL)AMINO) ETIL)FOSFORIL) METIL)PROPANOIL)-L-ALANINA

N° BR112022009690A2

((2S)-3--2-((히드록시((1R)-1--L-알라닌의 이나트륨 염의 공업적 제조 방법

N° KR20220113439A

AMINO ACID DERIVATIVES CONTAINING A DISULFANYL GROUP AS AN INHIBITOR OF NEP AND APN FOR THE PREVENTION AND TREATMENT OF TRIGEMINAL NERVE PAIN

N° ZA202004702B

Amino acid derivatives containing a disulfanyl group in the form of an nep and apn inhibitor for the prevention and treatment of trigeminal nerve pain

N° IL276242A

네프릴리신 (NEP) 저해제, 특히 혼합 아미노펩티다아제 N (APN) 및 네프릴리신 (NEP) 저해제로서의 N-포르밀히드록실아민

N° KR20220029734A

N-FORMYLHYDROXYLAMINES AS NEPRILYSIN (NEP) INHIBITORS, IN PARTICULAR AS MIXED INHIBITORS OF AMINOPEPTIDASE N (APN) AND NEPRILYSIN (NEP).

N° MX2022000269A

N-formylhydroxylamines as neprilysin (NEP) inhibitors, in particular as mixed aminopeptidase N (APN) and neprilysin (NEP) inhibitors

N° TW202116727A

N-formilhidroxilaminas como inibidores da neprilisina (nep) e, em praticular, como inibidores mistos da aminopeptidase n (apn) e da neprilisina (nep)

N° BR112021026774A2

N-FORMYLHYDROXYLAMINES AS NEPRILYSIN (NEP) INHIBITORS, IN PARTICULAR AS MIXED INHIBITORS OF AMINOPEPTIDASE N (APN) AND NEPRILYSIN (NEP)

N° CA3145838A1

N-FORMYLHYDROXYLAMINES AS NEPRILYSIN (NEP) INHIBITORS, IN PARTICULAR AS MIXED AMINOPEPTIDASE N (APN) AND NEPRILYSIN (NEP) INHIBITORS

N° US2022289668A1

N-FORMYLHYDROXYLAMINES AS NEPRILYSIN (NEP) INHIBITORS, IN PARTICULAR AS MIXED INHIBITORS OF AMINOPEPTIDASE N (APN) AND NEPRILYSIN (NEP)

N° WO2021005294A1

N-formylhydroxylamine as neprilysin (NEP) inhibitors, in particular as mixed inhibitors of aminopeptidase N (APN) and neprilysin (NEP)

N° CN114341109A

Procédé de préparation industrielle du sel disodique de ((2S)-3-([1,1'-biphenyl]-4-yl)-2-((hydroxy((1R)-1-(((1-(isobutyryloxy)ethoxy)carbonyl)amino)ethyl)phosphoryl) methyl)propanoyl)-L-alanine

N° FR3104581A1

AMINOPHOSPHINIC DERIVATIVES FOR PREVENTING AND TREATING EYE INFLAMMATION

N° ZA201906154B

Aminophosphinic derivatives for preventing and treating eye inflammation

N° IL269143A

N-Formylhydroxylamines en tant qu’inhibiteurs mixtes de l’aminopeptidase N (APN) et de la néprilysine (NEP)

N° FR3098217A1

Methods of treating eye pain with aminophosphinic derivatives

N° US2019167701A1

Amino acid derivatives containing a disulfanyl group as an inhibitor of nep and apn for the prevention and treatment of trigeminal nerve pain

N° TW201940164A

AMINO ACID DERIVATIVES CONTAINING A DISULFANYL GROUP IN THE FORM OF AN NEP AND APN INHIBITOR FOR THE PREVENTION AND TREATMENT OF TRIGEMINAL NERVE PAIN

N° CN111989096A

Aminosyrederivater med en disulfanylgruppe i form af en NEP- og APN-inhibitor til forebyggelse og behandling af smerter, som vedrører trigeminusnerven

N° DK3743059T3

Amino acid derivatives containing a disulfanyl group in the form of an NEP and APN inhibitor for the prevention and treatment of trigeminal nerve pain

N° US2021052539A1

AMINO ACID DERIVATIVES CONTAINING A DISULFANYL GROUP IN THE FORM OF AN NEP AND APN INHIBITOR FOR THE PREVENTION AND TREATMENT OF TRIGEMINAL NERVE PAIN.

N° MX2020007908A

AMINO ACID DERIVATIVES CONTAINING A DISULFANYL GROUP IN THE FORM OF AN NEP AND APN INHIBITOR FOR THE PREVENTION AND TREATMENT OF TRIGEMINAL NERVE PAIN

N° EP3743059A1

AMINO ACID DERIVATIVES CONTAINING A DISULFANYL GROUP IN THE FORM OF AN NEP AND APN INHIBITOR FOR THE PREVENTION AND TREATMENT OF TRIGEMINAL NERVE PAIN

N° CA3089350A1

AMINO ACID DERIVATIVES CONTAINING A DISULFANYL GROUP IN THE FORM OF AN NEP AND APN INHIBITOR FOR THE PREVENTION AND TREATMENT OF TRIGEMINAL NERVE PAIN

N° WO2019145507A1

Derivados aminoácidos que contienen un grupo disulfanilo en forma de un inhibidor de NEP y de APN para la prevención y el tratamiento de los dolores relacionados con el nervio trigémino

N° ES2936872T3

derivados de aminoácidos contendo grupo dissulfanila como um inibidor de nep e apn para a prevenção e tratamento de dor do nervo trigêmeo

N° BR112020014845A2

삼차 신경통의 예방 및 치료를 위한 NEP 및 APN 의 저해제로서 디술파닐기를 함유하는 아미노산 유도체

N° KR20200115562A

AMINOPHOSPHINIC DERIVATIVES FOR PREVENTING AND TREATING EYE PAIN

N° HK1259181A1

AMINOPHOSPHINIC DERIVATIVES FOR PREVENTING AND TREATING EYE PAIN

N° ZA201804037B

AMINOPHOSPHINIC DERIVATIVES FOR PREVENTING AND TREATING EYE PAIN

N° MX2018006580A

Aminophosphinic derivatives for preventing and treating eye pain

N° IL259562A

INDUSTRIAL PROCESS FOR THE PREPARATION OF (5S,10S)-10-BENZYL-16-METHYL-11,14,18-TRIOXO-15,17,19-TRIOXA-2,7,8-TRITHIA-12-AZAHENICOSAN-5-AMINIUM (E)-3-CARBOXYACRYLATE SALT

N° ZA201803105B

INDUSTRIAL PROCESS FOR THE PREPARATION OF (5S,10S)-10-BENZYL-16-METHYL-11,14,18-TRIOXO-15,17,19-TRIOXA-2,7,8-TRITHIA-12-AZAHENICOSAN-5-AMINIUM (E)-3-CARBOXYACRYLATE SALT

N° MX2018004631A

Industrial process for the preparation of (5s,10s)-10-benzyl-16-methyl-11,14,18-trioxo-15,17,19-trioxa-2,7,8-trithia-12-azahenicosan-5-aminium (e)-3-carboxyacrylate salt

N° IL258663A

Aminophosphinic derivatives for preventing and treating eye inflammation

N° US2021213036A1

Aminophosphinic derivatives for preventing and treating eye inflammation

N° TW201840321A

AMINOPHOSPHINIC DERIVATIVES FOR PREVENTING AND TREATING OCULAR INFLAMMATION

N° CN110352060A

AMINOPHOSPHINIC DERIVATIVES FOR PREVENTING AND TREATING OCULAR INFLAMMATION

N° WO2018162860A1

눈 염증의 예방 및 치료를 위한 아미노포스핀 유도체

N° KR20190127786A

AMINOPHOSPHINIC DERIVATIVES FOR PREVENTING AND TREATING OCULAR INFLAMMATION

N° CA3055461A1

AMINOPHOSPHINIC DERIVATIVES FOR PREVENTING AND TREATING OCULAR INFLAMMATION.

N° MX2019010648A

derivados aminofosfínicos para a prevenção e tratamento de inflamação no olho

N° BR112019016458A2

DERIVES AMINOACIDES CONTENANT UN GROUPEMENT DISULFANYLE SOUS FORME D'UN INHIBITEUR DE NEP ET D'APN POUR LA PREVENTION ET LE TRAITEMENT DES DOULEURS RELATIVES AU NERF TRIJUMEAU

N° FR3077201A1

DERIVES AMINOPHOSPHINIQUES POUR LA PREVENTION ET LE TRAITEMENT DE L'INFLAMMATION OCULAIRE

N° FR3063635A1

AMINOPHOSPHINIC DERIVATIVES FOR PREVENTING AND TREATING EYE PAIN

N° CA3006365A1

Derivados aminofosfínicos para la prevención y el tratamiento de los dolores oculares

N° ES2773148T3

AMINOPHOSPHINIC DERIVATIVES FOR PREVENTING AND TREATING EYE PAIN

N° US2018344753A1

derivados aminofosfínicos para prevenção e tratamento das dores oculares

N° BR112018010007A2

AMINOPHOSPHINIC DERIVATIVES FOR PREVENTING AND TREATING EYE PAIN

N° EP3383403A1

AMINOPHOSPHINIC DERIVATIVES FOR PREVENTING AND TREATING EYE PAIN

N° CN112121008A

AMINOPHOSPHINIC DERIVATIVES FOR PREVENTING AND TREATING EYE PAIN

N° WO2017093322A1

Aminophosphinic derivatives for preventing and treating ocular pain

N° TW201726146A

눈 통증의 예방 및 치료를 위한 아미노포스핀산 유도체

N° KR20180095555A

Aminofosfonisk derivat til forebyggelse og behandling af øjesmerter

N° DK3383403T3

Proceso industrial para la preparación de la sal de (E)-3-carboxiacrilato de (5S,10S)-10-bencil-16-metil-11,14,18-trioxo-15,17,19-trioxa-2,7,8-tritia-12-azahenicosan-5-aminio

N° ES2818185T3

Industrial process for the preparation of (5S, 10S)-10-benzyl-16-methyl-11, 14, 18-trioxo-15, 17, 19-trioxa-2,7,8-trithia-12-azahenicosan-5-aminium(E)-3-carboxyacrylate salt

N° US2018305308A1

INDUSTRIAL PROCESS FOR THE PREPARATION OF (5S,10S)-10-BENZYL-16-METHYL-11,14,18-TRIOXO-15,17,19-TRIOXA-2,7,8-TRITHIA-12-AZAHENICOSAN-5-AMINIUM (E)-3-CARBOXYACRYLATE SALT

N° CA3016962A1

INDUSTRIAL PROCESS FOR THE PREPARATION OF (5S,10S)-10-BENZYL-16-METHYL-11,14,18-TRIOXO-15,17,19-TRIOXA-2,7,8-TRITHIA-12-AZAHENICOSAN-5-AMINIUM (E)-3-CARBOXYACRYLATE SALT

N° WO2017064250A1

Industriel fremgangsmåde til fremstilling af (5s,10s)-10-benzyl-16-methyl-11,14,18-trioxo-15,17,19-trioxa-2,7,8-trithia-12-azahenicosan-5-aminium (e)-3-carboxyacrylat-salt

N° DK3362433T3

INDUSTRIAL PROCESS FOR THE PREPARATION OF (5S,10S)-10-BENZYL-16-METHYL-11,14,18-TRIOXO-15,17,19-TRIOXA-2,7,8-TRITHIA-12-AZAHENICOSAN-5-AMINIUM (E)-3-CARBOXYACRYLATE SALT

N° EP3362433A1

processo industrial para a preparação de sal de (e)-3-carboxiacrilato de (5s,10s)-10-benzil-16-metil-11,14,18-trioxo-15,17,19-trioxa-2,7,8-tritia-12-aza-henicosan-5-amínio

N° BR112018007505A2

(5S,10S)-10-벤질-16-메틸-11,14,18-트리옥소-15,17,19-트리옥사-2,7,8-트리티아-12-아자헤니코산-5-아미늄 (E)-3-카르복시아크릴레이트 염의 제조용 산업 공정

N° KR20180095507A

Industrial process for the preparation of (5s,10s)-10-benzyl-16-methyl-11,14,18-trioxo-15,17,19-trioxa-2,7,8-trithia-12-azahenicosan-5-aminium(e)-3-carboxyacrylate salt

N° TW201718479A

MIXED INHIBITORS OF AMINOPEPTIDASE AND OF EPRILYSINE

N° HK1212675A1

Agents for the Molecular Imaging of Serine-Protease in Human Pathologies

N° US2016206762A1

DERIVES AMINOPHOSPHINIQUES POUR LA PREVENTION ET LE TRAITEMENT DES DOULEURS OCULAIRES

N° FR3044227A1

Mixed inhibitors of aminopeptidase n and neprilysine

N° IL238406A0

MIXED INHIBITORS OF AMINOPEPTIDASE N AND OF NEPRILYSINE

N° WO2014064166A1

Mixed inhibitors of aminopeptidase n and neprilysin

N° TW201420558A

MIXED INHIBITORS OF AMINOPEPTIDASE N AND NEPRYLISIN

N° EP2912015A1

COMPOUNDS COMBINING AN AMINOPEPTIDASE N INHIBITOR AND A NEPRILYSIN INHIBITOR THROUGH THE INTERMEDIARY OF A CLEAVABLE DISULFIDE BRIDGE IN VIVO

N° CA2888728A1

Inhibidores mixtos de la aminopeptidasa N y de la neprilisina

N° ES2668902T3

BLANDEDE INHIBITORER AF AMINOPEPTIDASE N OG NEPRILYSIN

N° DK2912015T3

Mixed inhibitors of aminopeptidase N and neprilysin

N° US2015299116A1

NEPRILYSIN INHIBITORS

N° WO2014064162A1

INHIBITEURS DE NEPRILYSINE

N° FR2997080A1

INHIBITEURS MIXTES DE L'AMINOPEPTIDASE N ET DE LA NEPRILYSINE

N° FR2997081A1

AGENTS FOR THE MOLECULAR IMAGING OF SERINE-PROTEASE IN HUMAN PATHOLOGIES

N° EP2646058A1

Agents for the molecular imaging of serine-protease in human pathologies

N° US2013243691A1

AGENTS FOR THE MOLECULAR IMAGING OF SERINE-PROTEASE IN HUMAN PATHOLOGIES

N° WO2012072819A1

SUBSTRATES THE FLUORESCENCE OF WHICH IS SUPPRESSED, PREPARATION THEREOF, AND USE THEREOF FOR IDENTIFYING, DETECTING, AND ASSAYING LEGIONELLA PNEUMOPHILIA

N° US2013203097A1

NOVEL SUBSTRATES THE FLUORESCENCE OF WHICH IS SUPPRESSED, PREPARATION THEREOF, AND USE THEREOF FOR IDENTIFYING, DETECTING, AND ASSAYING LEGIONELLA PNEUMOPHILIA

N° WO2012010668A1

NOVEL SUBSTRATES THE FLUORESCENCE OF WHICH IS SUPPRESSED, PREPARATION THEREOF, AND USE THEREOF FOR IDENTIFYING, DETECTING, AND ASSAYING LEGIONELLA PNEUMOPHILIA

N° CA2813219A1

Nuevos sustratos con fluorescencia reprimida, su preparación y su uso para la identificación, la detección y el análisis de Legionella pneumophila

N° ES2549498T3

NOVEL SUBSTRATES THE FLUORESCENCE OF WHICH IS SUPPRESSED, PREPARATION THEREOF, AND USE THEREOF FOR IDENTIFYING, DETECTING, AND ASSAYING LEGIONELLA PNEUMOPHILIA

N° EP2596124A1

NOUVEAUX SUBSTRATS A FLUORESCENCE REPRIMEE, LEUR PREPARATION ET LEUR UTILISATION POUR L'IDENTIFICATION, LA DETECTION ET LE DOSAGE DE LEGIONELLA PNEUMOPHILA

N° FR2963022A1